Technology for single-cell analysis

The center develops single-cell proteomics technology that is high-throughput, robust, and easy to adopt.



Technologies for analyzing protein in single cells

Single Cell ProtEomics by MS (SCoPE-MS) and its second generation, SCoPE2, use multiplexed experimental designs in which proteins from single cells and from the total cell lysate of a small group of cells (called carrier proteins) are barcoded with isobaric mass tags and then combined. This design, utilizes the isobaric carrier to reduce the loss of proteins from single cells adhering to equipment surfaces while simultaneously enhancing peptide identification.

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About the single-cell proteomics center

The single-cell proteomics center is located at Northeastern University in Boston, MA, USA. Questions about the center should be addressed to Prof. Nikolai Slavov.